Survey the Interference of Glutamate – Histamine in Central Nervous System in food intake at Broiler Chickens (A Physiological Approach to Neuro-Endocrinal system in poultry)

Glutamate and histamine are two inhibitory factors of appetite in central nervous system of birds. In the present study, interference effect of glutamate-histamine was evaluated. The broiler weighing 700±50gr, implanted sterile canule in right ventricle of their brine, were used. Animals were fasted for 24 hours before intra-ventricular micro-injection. After canule-implantation the birds were divided to different groups in terms of kind of injection drugs. Each group included 8 broilers and one group was considered as control. Glutamate, histamine, histamine antagonist and glutamate-histamine solutions were injected to right ventricle of brain and then the amount of food intake in all groups in minutes 15, 30,45,60,90,120,180 and 240 after injection was measured. Results showed that intra-ventricular injection of glutamate, histamine and histamine-glutamate caused statistically considerable decrease in food intake compared to control groups (P<0.05), whereas histamine antagonist induced significant increase in food intake in comparison to control group in all times (P<0.05).In minutes 30,45,60,120 and 180,appetite in glutamate-histamine was less than group glutamate but finally in minute 240 there was not seen any significant difference between two groups. In conclusion, it seemed the inhibitory effect of histamine on glutamate receptors prevented the intensive effect of contemporarily injection of these two drugs.